Table 1. Common nAChR Subunit Gene Variant Associations with the FTND Score.

SNP ID	A1a	A2b	Gene	Type	MAF	Add Pc	Dom Pd
rs2280781	C	T	CHRNB2	5′ UTR	0.101	0.221	0.280
rs4845378	G	T	CHRNB2	Intron	0.097	0.258	0.258
rs2072660	T	C	CHRNB2	3′ UTR	0.244	0.003	0.006
rs2072661	G	A	CHRNB2	3′ UTR	0.245	0.002	0.004
rs4292956	C	T	CHRNB2	3′ UTR	0.066	0.472	0.476
rs2472553	G	A	CHRNA2	Non-syn	0.139	0.571	0.493
rs13277254	G	A	CHRNB3	Up	0.234	0.829	0.875
rs13280301	A	G	CHRNB3	Up	0.178	0.675	0.798
rs6474413	C	T	CHRNB3	Up	0.232	0.746	0.702
rs4950	G	A	CHRNB3	5′ UTR	0.236	0.808	0.854
rs2304297	G	C	CHRNA6	3′ UTR	0.244	0.557	0.985
ss161151744	C	T	CHRNA7	Syn	0.066	0.314	0.314
rs569207	C	T	CHRNA5	Intron	0.196	0.134	0.149
rs16969968	G	A	CHRNA5	Non-syn	0.367	0.433	0.322
rs615470	T	C	CHRNA5	3′ UTR	0.381	0.330	0.329
rs8192482	C	T	CHRNA5	3′ UTR	0.368	0.489	0.388
rs564585	A	G	CHRNA5	3′ UTR	0.237	0.080	0.139
rs12899226	T	G	CHRNA3	Down	0.052	0.104	0.104
rs660652	A	G	CHRNA3	3′ UTR	0.383	0.283	0.329
rs472054	A	G	CHRNA3	3′ UTR	0.379	0.381	0.367
rs578776	A	G	CHRNA3	3′ UTR	0.247	0.053	0.112
rs1051730	G	A	CHRNA3	Syn	0.367	0.455	0.359
rs3743075	T	C	CHRNA3	Syn	0.378	0.292	0.305
rs3743074	G	A	CHRNA3	Intron	0.378	0.336	0.324
rs8040868	T	C	CHRNA3	Syn	0.429	0.981	0.813
rs8192475	C	T	CHRNA3	Non-syn	0.050	0.094	0.094
rs12914008	G	A	CHRNB4	Non-syn	0.051	0.100	0.100
rs3813567	G	A	CHRNB4	Up	0.157	0.370	0.275
rs2302765	T	C	CHRNB1	Intron	0.159	0.729	1.000
rs12452047	A	G	CHRNB1	Intron	0.166	0.616	0.808
rs7210231	C	A	CHRNB1	Intron	0.199	0.124	0.017
rs2302761	C	T	CHRNB1	Intron	0.202	0.233	0.078
rs2302763	T	C	CHRNB1	Intron	0.164	0.679	0.889
rs2302764	T	C	CHRNB1	3′ UTR	0.160	0.049	0.045
rs3827020	T	C	CHRNA4	Intron	0.143	0.521	0.865
rs45442394	G	A	CHRNA4	Intron	0.060	0.431	0.717
rs1044397	C	T	CHRNA4	Syn	0.492	0.305	0.608
rs1044396	G	A	CHRNA4	Syn	0.488	0.215	0.467
rs2229960	A	G	CHRNA4	Syn	0.057	0.870	0.758
rs2229959	C	A	CHRNA4	Syn	0.119	0.837	0.806
rs1044394	A	G	CHRNA4	Syn	0.067	0.784	0.678
rs6090384	T	C	CHRNA4	Intron	0.060	0.830	0.933
rs2273505	C	T	CHRNA4	Intron	0.062	0.740	0.725
rs2273506	G	A	CHRNA4	Syn	0.061	0.580	0.562

^aA1=allele 1.

^bA2=allele 2.

^cAdd=additive model.

^dDom=dominant model.

The bold values are for P<0.05.