Figure 1.

Social interaction deficits following late prenatal immune challenge. Social interaction was assessed by analyzing the relative exploration time between an unfamiliar congenic mouse (‘mouse') and an inanimate dummy object (‘dummy'). The line plots depict the relative exploration time as a function of successive 1-min bins, and the bar plot shows the mean exploration time per bin. Control offspring born to vehicle-treated mothers displayed a significant preference towards the unfamiliar congenic mouse, indicating intact social interaction. On the other hand, offspring exposed to prenatal Poly-I:C treatment in late gestation displayed no such preference. ^*P<0.05, based on restricted ANOVAs. All values are means±SEM.