Figure 2.

Presence of anhedonic behavior following late prenatal immune challenge. Anhedonic behavior was assessed using a 2-day (48 h) sucrose preference test, in which animals had free choice between regular tap water and a 0.5% sucrose solution. (a) The graph depicts sucrose preference as indexed by a percentage score (sucrose consumption/(total liquid consumption) × 100%) obtained on two consecutive test days (day 1 and 2). Adult offspring exposed to prenatal Poly-I:C treatment in late gestation displayed a significant reduction in the sucrose preference index compared with adult control offspring. ^**P<0.01, signifies the main effect of prenatal treatment in the corresponding RM-ANOVA. (b) The graph shows the total fluid (water+sucrose solution) consumption on the two consecutive test days. Prenatal Poly-I:C treatment did not affect total fluid intake across the two test days. All values are means±SEM.