Figure 3.

Presence of abnormally enhanced LI following late prenatal immune challenge. The LI effect was studied in a two-way active avoidance procedure, in which pre-exposed (PE) subjects were presented with a low number of the CS before conditioning, whereas NPE subjects were not pre-exposed to the CS. The graph depicts the response latency as a function of blocks of 10 trials in male and female offspring. Male but not female offspring exposed to prenatal Poly-I:C treatment in late gestation displayed a significant LI effect (ie, reduced response latency in PE relative to NPE subjects) under parametric conditions, in which control offspring did not display LI. ^*P<0.05, signifies the significant main effect of pre-exposure in the corresponding ANOVA restricted to male Poly-I:C offspring. All values are means±SEM.