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. 2010 Aug 25;35(12):2462–2478. doi: 10.1038/npp.2010.129

Figure 6.

Figure 6

Effects of late prenatal immune challenge on basal levels of excitatory amino acids. Levels of the excitatory amino acids glutamate and aspartate were determined in postmortem brain tissue using HPLC. The contents of these excitatory amino acids were measured in the mPFC, AMY, CPu, NAc, dHPC, and vHPC. All levels are expressed as ng per mg fresh tissue weight. (a) Glutamate contents in adult control and Poly-I:C offspring. Symbol (§) signifies the presence of a sex-dependent effect in the mPFC, as further depicted by the inlets showing glutamate levels in the mPFC of male (M) and female (F) offspring born to Poly-I:C-exposed mothers or control mothers. **P<0.01, based on the ANOVA restricted to males. ##P<0.01, based on ANOVA in males and females. (b) Aspartate contents in adult control and Poly-I:C offspring. Symbol (§) signifies the presence of a sex-dependent effect in the mPFC, as further depicted by the inlets showing aspartate levels in the mPFC of male (M) and female (F) offspring born to Poly-I:C-exposed mothers or control mothers. ***P<0.001, based on the ANOVA restricted to males. ##P<0.01, based on ANOVA of dHPC contents in males and females. All values are means±SEM.