Figure 7.

Effects of late prenatal immune challenge on basal levels of inhibitory amino acids. Levels of the inhibitory amino acids GABA and taurine were determined in postmortem brain tissue using HPLC. The contents of these inhibitory amino acids were measured in the mPFC, AMY, CPu, NAc, dHPC, and vHPC. All levels are expressed as ng per mg fresh tissue weight. (a) GABA contents in adult control and Poly-I:C offspring. Symbol (§) signifies the presence of a sex-dependent effect in the dHPC, as further depicted by the inlets showing GABA levels in the dHPC of male (M) and female (F) offspring born to Poly-I:C-exposed mothers or control mothers. ^*P<0.05, based on the ANOVA restricted to females. (b) Taurine contents in adult control and Poly-I:C offspring. Symbol (§) signifies the presence of sex-dependent effects, as further depicted by the inlets showing GABA levels in the mPFC and dHPC of male (M) and female (F) offspring born to Poly-I:C-exposed mothers or control mothers. ^**P<0.01, based on the ANOVA restricted to males; ^*P<0.01, based on the ANOVA restricted to females. All values are means±SEM.