Table 2. Statistically Significant Results after Multiple Testing Correction* of the Single-Marker Association Study in Mood Disorders Adjusted by Sex.
| Gene | dbSNP | Alelles (A/a) |
Genotype counts, n (%) |
Model | OR (95%CI) | Gene-wide permuted p-value | Global permuted p-value | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Cases |
Controls |
|||||||||||
| AA | Aa | aa | AA | Aa | aa | |||||||
| Mood disorders (MDD+BD) | ||||||||||||
| CRY1 | rs2287161 | C/G | 178 (34.8) | 243 (47.5) | 91 (17.8) | 110 (25.7) | 201 (47.0) | 117 (27.3) | Log-additive | 0.71 (0.59-0.85) | 0.002 | 0.01* |
| NPAS2 | rs11123857 | A/G | 272 (52.5) | 198 (38.2) | 48 (9.3) | 262 (62.4) | 139 (33.1) | 19 (4.5) | Log-additive | 1.44 (1.16-1.79) | 0.009 | 0.07 |
| VIPR2 | rs885861 | T/C | 128 (27.2) | 215 (45.7) | 127 (27.0) | 121 (29.8) | 211 (52.0) | 74 (18.2) | Recessive | 1.65 (1.19-2.30) | 0.01 | 0.34 |
| Unipolar MDD | ||||||||||||
| CRY1 | rs2287161 | C/G | 116 (36.2) | 153 (47.8) | 51 (15.9) | 110 (25.7) | 201 (47.0) | 117 (27.3) | Log-additive | 0.66 (0.53-0.81) | 0.0001 | 0.007* |
| NPAS2 | rs11123857 | A/G | 166 (51.1) | 126 (38.8) | 33 (10.2) | 262 (62.4) | 139 (33.1) | 19 (4.5) | Log-additive | 1.51 (1.19-1.92) | 0.008 | 0.04 |
| Bipolar disorder | ||||||||||||
| CLOCK | rs10462028 | G/A | 102 (52.3) | 66 (33.8) | 27 (13.8) | 182 (42.4) | 207 (48.3) | 40 (9.3) | Codominant | 0.55 (0.38-0.80) | 0.02 | 0.83 |
| VIP | rs17083008 | G/A | 112 (57.1) | 62 (31.6) | 22 (11.2) | 230 (60.5) | 133 (35.0) | 17 (4.5) | Recessive | 2.68 (1.37-5.22) | 0.016 | 0.38 |
*Statistically significant after correction for multiple testing at experiment level (the different phenotypes tested set permuted p-value <0.025).