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. 2009 Dec 9;35(4):870–880. doi: 10.1038/npp.2009.197

Figure 1.

Figure 1

APPswe/PS1dE9 mice develop contextual memory deficits with age. (a) Wild-type (WT) and APPswe/PS1dE9 (4- or 6-month-old) mice were trained in a contextual fear conditioning paradigm (4 months: WT n=11, APP/PS1 n=11; 6 months: WT n=6, APP/PS1 n=7). After 24 h, all mice were reexposed to the conditioning context. Percent freezing was calculated for each animal. Analysis of variance (ANOVA), **P<0.01. (b) WT and APP/PS1 (6-month-old) mice were trained in a contextual fear conditioning paradigm (WT n=7, APP/PS1 n=7). After 1 h, all mice were reexposed to the context to assess short-term memory. Percent freezing was calculated for each animal. ANOVA, P>0.05.