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. 2009 Dec 9;35(4):870–880. doi: 10.1038/npp.2009.197

Figure 2.

Figure 2

Sodium valproate treatment rescues contextual memory formation in APPswe/PS1dE9 mutants. (a) Wild-type (WT) and APP/PS1 mice were injected with either vehicle (VEH) or 100 mg/kg sodium valproate (VPA) daily for 2 weeks (VEH: WT n=7, APP/PS1 n=7; VPA: WT n=6, APP/PS1 n=7). All mice were then trained in a contextual fear conditioning paradigm and tested for long-term memory 24 h later by reexposure to the conditioning context. Freezing was measured for each animal. Two-way univariate analyses with Scheffe's post hoc tests were performed. *P<0.05, **P<0.01. (b) Exploratory activity was measured for each animal during 150 s period before the footshock. (c) Percent freezing was calculated for each animal during the 28 s period immediately after the footshock.