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. 2009 Dec 9;35(4):870–880. doi: 10.1038/npp.2009.197

Figure 4.

Figure 4

Sodium butyrate (NaB) rescues memory deficits in APPswe/PS1dE9 mice. (a) Wild-type (WT) and APP/PS1 (6-month-old) mice were injected with either vehicle (VEH) or 1.2 g/kg NaB for 21 days (VEH: WT n=9, APP/PS1 n=9; NaB: WT n=10, APP/PS1 n=10). All mice were then trained in a contextual fear conditioning paradigm and tested for long-term memory 24 h later. Freezing was measured for each animal. Two-way univariate analyses with Scheffe's post hoc tests were performed (Drug by Genotype: F(3,34)=4.81, P<0.05; Veh WT vs Veh APP/PS1: t(16)=4.14, P<0.005; Veh APP/PS1 vs NaB APP/PS1: t(17)=−3.57, P<0.005). **P<0.01. (b) Exploratory activity was measured for each animal during 150 s period before the footshock. (Drug: F(3,34)=0.52, Genotype: F(3,34)=0.47, Drug by Genotype: F(3,34)=0.14; P>0.05 for all). (c) Percent freezing was calculated for each animal during the 28 s period immediately following the footshock. (Drug: F(3,34)=0.01, Genotype: F(3,34)=2.28, Drug by Genotype: F(3,34)=0.07; P>0.05 for all).