Table 1. IC50 Values of HDAC Inhibitors that Increase Memory Formation in APPswe/PS1dE9 Mutant Mice.
| Compound | Class I | ||||
|---|---|---|---|---|---|
| HDAC1 | HDAC2 | HDAC3 | HDAC8 | ||
| Butyric acid | 8.3±0.5 | 7.0±0.2 | 4.8±0.2 | 10.4±0.7 | |
| Valproate | 35.5±3.1 | 59.3±3.6 | 218.5±22.5 | 97.1±5.8 | |
| SAHA | 0.002±0.0001 | 0.003±0.0001 | 0.006±0.0003 | 0.7±0.07 | |
| Compound | Class IIa | Class IIb | |||
| |
HDAC4 |
HDAC5 |
HDAC7 |
HDAC9 |
HDAC6 |
| Butyric acid | 5725±98.3 | 6403±370 | 4380±441 | 5614±359 | 5881±1303 |
| Valproate | >15 000 | >15 000 | >15 000 | >15 000 | >20 000 |
| SAHA | >25 | >15 | >25 | >25 | 0.004±0.0004 |
IC50 values (μM) of HDAC inhibitors that increase memory formation in APPswe/PS1dE9 mutant mice using recombinant human HDAC1-9 and an in vitro deacetylase assay with synthetic substrates for both class I and class IIa/IIb HDACs. Data shown are average values±s.d. from n=2 replicates performed on different 384-well plates.