Table 2. Hormonal and Drug Level Measures during FEN Challenge.
Variables | Non-patient comparison | Depressed non-attempters | Past attempters | Future attempters | p-valuea | Contrastb |
---|---|---|---|---|---|---|
Baseline prolactin | 10.1±3.9 | 9.0±3.8 | 8.1±3.8 | 7.5±3.9 | 0.43 | |
Peak change in prolactin | 13.3±6.2 | 10.7±5.3 | 8.4±5.4 | 8.7±5.5 | 0.10 | |
Area under the curve prolactin | 75.4±18.8 | 64.5±18.2 | 54.6±18.3 | 51.2±18.7 | 0.01 | FA, PA<C |
Baseline cortisol | 12.5±4.8 | 14.7±4.7 | 12.3±4.7 | 15.4±4.8 | 0.24 | |
Peak change in cortisol | 5.0±3.8 | 3.9±3.7 | 5.1±3.7 | −0.3±3.8 | 0.01 | FA<PA, N, C |
Area under the curve cortisol | 59.8±15.2 | 62.5±18.0 | 63.0±21.8 | 52.4±20.3 | 0.55 | |
Fenfluramine plus norfenfluramine levels | 67.3±20.8 | 59.7±20.2 | 62.3±20.4 | 58.1±20.8 | 0.70 |
Omnibus ANCOVA with age and sex as covariates for baseline measures, and with age, sex, and fenfluramine/norfenfluramine levels as covariates for peak change and area under the curve.
Tukey LSD post hoc test.