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. 2010 Jan 20;35(5):1209–1225. doi: 10.1038/npp.2009.227

Table 3. Significant Activations and Deactivations for the Contrasts TAKING OUT, BEGIN, LAST PUFF, and END in Nonsmokers, Nondeprived Smokers, and Deprived Smokers.

Contrast Structures Side x y z tmax score Cluster size pcorr
Nonsmokers                
TAKING OUT                
  No significant results              
                 
BEGIN
 Activations                
  Orbitofrontal cortex L 0 54 −15 4.29 292 0.009
  Orbitofrontal cortex R 3 54 −18 4.22 180 0.011
  Anterior cingulate cortex R 6 45 27 3.47 138 0.034
  Dorsolateral prefrontal cortex R 18 45 36 4.29 54 0.015
 Deactivations                
  No significant results              
LAST PUFF
  No significant results              
END                
  No significant results              
                 
Nondeprived smokers
TAKING OUT
 Activations                
  Orbitofrontal cortex L −42 18 −9 5.40 240 <0.001
  Anterior cingulate cortex L 3 21 21 3.69 248 0.020
  Anterior cingulate cortex R 6 18 24 3.82 44 0.012
  Dorsolateral prefrontal cortex L −33 3 54 5.90 450 <0.001
  Dorsolateral prefrontal cortex R 27 0 57 4.64 198 0.004
  Insular cortex L −39 15 −6 6.43 259 <0.001
  Insular cortex R 33 24 3 4.88 137 <0.001
                 
 Deactivations
  Ventral striatum R 18 9 −12 3.25 56 0.025
  Anterior cingulate cortex R 12 36 12 3.95 80 0.008
  Dorsolateral prefrontal cortex R 36 −12 69 4.56 14 0.006
BEGIN                
 Activations                
  Ventral tegmental area   0 −15 −9 3.39 26 0.001
  Ventral striatum L −12 12 −6 3.15 35 0.029
  Orbitofrontal cortex L −6 45 −6 4.98 393 0.001
  Orbitofrontal cortex R 30 24 −24 4.18 453 0.013
  Anterior cingulate cortex L 3 24 24 5.35 365 <0.001
  Anterior cingulate cortex R 3 24 27 5.34 214 <0.001
  Dorsolateral prefrontal cortex L −18 60 3 4.73 811 0.003
  Dorsolateral prefrontal cortex R 33 −3 54 5.11 189 0.001
  Hippocampus L −24 −27 −18 3.69 203 0.025
  Insular cortex L −33 21 3 5.18 169 <0.001
  Insular cortex R 30 24 −21 4.16 18 0.005
 Deactivations                
  No significant results              
LAST PUFF
 Activations
  Ventral tegmental area   3 −18 −15 4.60 26 <0.001
  Ventral striatum L −15 6 −12 3.64 22 0.007
  Ventral striatum R 15 9 0 3.38 91 0.017
  Orbitofrontal cortex L −42 36 −6 7.20 833 <0.001
  Orbitofrontal cortex R 36 30 −15 5.15 861 <0.001
  Anterior cingulate cortex L −6 30 30 6.61 332 <0.001
  Anterior cingulate cortex R 3 18 27 4.86 177 <0.001
  Dorsolateral prefrontal cortex L −42 48 24 6.79 2017 <0.001
  Dorsolateral prefrontal cortex R 42 18 39 6.26 2231 <0.001
  Amygdala L −30 0 −27 5.85 69 <0.001
  Amygdala R 36 0 −24 5.34 80 <0.001
  Hippocampus L −24 −27 −21 5.33 465 <0.001
  Hippocampus R 33 −15 −12 6.17 495 <0.001
  Insular cortex L −30 21 −9 6.09 513 <0.001
  Insular cortex R 39 0 6 5.47 421 <0.001
 Deactivations                
  No significant results              
END                
 Activations                
  Orbitofrontal cortex L −21 30 −12 6.72 393 <0.001
  Orbitofrontal cortex R 24 36 −15 4.05 148 0.020
  Dorsolateral prefrontal cortex L −39 9 33 4.39 56 0.010
  Dorsolateral prefrontal cortex R 51 42 9 4.71 196 0.003
  Hippocampus L −30 −39 −15 4.53 70 0.002
  Insular cortex L −36 9 −15 4.03 142 0.009
 Deactivations                
  Ventral striatum R 9 3 −9 3.97 16 0.003
  Anterior cingulate cortex L 3 39 15 4.19 96 0.004
  Anterior cingulate cortex R 15 36 12 5.20 159 <0.001
  Dorsolateral prefrontal cortex R 18 57 3 4.07 52 0.032
  Insular cortex R 42 −12 12 3.77 59 0.019
                 
Deprived smokers
TAKING OUT
 Activations                
  Orbitofrontal cortex L −12 51 −3 5.15 680 <0.001
  Orbitofrontal cortex R 24 36 −24 4.43 429 0.005
  Anterior cingulate cortex L −9 51 0 5.57 306 <0.001
  Anterior cingulate cortex R 3 36 0 4.48 84 0.001
  Dorsolateral prefrontal cortex L −15 54 6 5.38 859 <0.001
  Dorsolateral prefrontal cortex R 33 −12 63 4.17 260 0.023
  Hippocampus L −12 −39 6 4.99 152 <0.001
  Hippocampus R 15 −36 6 4.26 316 0.004
  Insular cortex L −45 6 0 5.61 303 <0.001
  Insular cortex R 48 9 −3 4.54 367 0.001
 Deactivations                
  No significant results              
                 
BEGIN
 Activations                
  Ventral tegmental area   3 −18 −21 3.66 16 0.002
  Orbitofrontal cortex L −12 48 −6 4.13 532 0.014
  Anterior cingulate cortex L −9 48 −3 3.68 113 0.021
  Dorsolateral prefrontal cortex L −21 −3 66 4.31 1015 0.013
  Dorsolateral prefrontal cortex R 36 −9 57 4.43 197 0.009
  Hippocampus L −30 −21 −27 3.92 151 0.012
  Hippocampus R 18 −3 −27 3.79 25 0.020
  Insular cortex L −39 3 9 3.73 158 0.022
 Deactivations                
  No significant results              
                 
LAST PUFF
 Activations                
  Ventral striatum L −3 12 −6 3.12 77 0.031
  Ventral striatum R 6 3 −9 3.26 63 0.024
  Orbitofrontal cortex L −36 42 −9 3.91 227 0.029
  Anterior cingulate cortex L −6 48 6 3.54 207 0.030
  Dorsolateral prefrontal cortex L −42 48 6 4.29 755 0.014
  Dorsolateral prefrontal cortex R 39 45 3 4.48 354 0.008
  Amygdala R 24 −9 −15 3.02 41 0.029
  Hippocampus L −18 −6 −33 3.71 211 0.023
  Hippocampus R 21 −6 −33 4.01 287 0.010
  Insular cortex L −42 3 9 4.12 305 0.006
  Insular cortex R 39 0 3 4.02 191 0.009
 Deactivations                
  No significant results              
END                
 Activations                
  Orbitofrontal cortex L −9 18 −15 3.80 235 0.041
  Orbitofrontal cortex R 3 27 −21 3.97 81 0.026
  Ventral striatum L −3 12 −18 4.24 25 0.001
                 
 Deactivations                
  Orbitofrontal cortex R 27 54 −3 4.14 125 0.015
  Dorsolateral prefrontal cortex L −18 6 66 3.91 206 0.049
  Dorsolateral prefrontal cortex R 24 51 0 4.58 648 0.005