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. 2009 Sep 2;35(1):239–257. doi: 10.1038/npp.2009.116

Figure 8.

Figure 8

A model diagram depicting changes in the modulation of GABAergic interneurons and pyramidal cells in the stratum oriens of sectors CA3/2 of normal controls and in the schizophrenia model. Excitatory afferent fibers from the basolateral amygdala (BLA) project to the apical dendrites of pyramidal neurons and to dendritic branches of fast-spiking GABA cells. When induced to fire, the GABAergic synapses on the pyramidal cell cause spontaneous inhibitory postsynaptic currents (IPSCs) to be generated in the cell body of the pyramidal cell. In the schizophrenia model, the GABA cells show an increase in Ih channels and their spike frequency. The pyramidal cells show a decrease in spontaneous IPSCs, rather than an increase. Consistent with this, a decrease in GABAergic synapses surrounding pyramidal neurons is shown in the photomicrographic inset in the middle of the diagram, suggesting that there may be a depletion of GABA in these synaptic terminals. In neural circuits, sometimes ‘more' results in ‘less'. See Gisabella et al (2009) for more details.