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. 2010 Mar 3;35(7):1531–1540. doi: 10.1038/npp.2010.23

Figure 5.

Figure 5

VPA effects on striatal BDNF distribution pattern. (a) The histograms show the percent of BDNF-positive FS interneurons and MS neurons in the striatum of naïve and VPA-treated wild types and Bsn mutants. Although in wild-type mice, the proportion of MS Calb-positive neurons that express BDNF protein was higher than the relative number of PV/BDNF-positive interneurons (***p<0.001), in epileptic mice the immunoreactivity of BDNF was similar in both neuronal subtypes. Chronic early treatment with VPA restored the ratio between PV/BDNF and Calb/BDNF cells in the striatum of epileptic mice (***p<0.001) to control levels. Early exposure to VPA in wild types increased the neurotrophin immunoreactivity in both neuronal subtypes, preserving the ratio between BDNF-positive MS neurons and FS interneurons that was similar to the one observed in naïve controls (***p<0.001). (b) After chronic treatment with VPA synaptic levels of striatal TrkB were similar in both Bsn mutant and wild-type mice (p>0.05). Histograms show the quantification of western blotting performed in TIF fractions.