Table 1. Serum Levels of Estradiol in Sham and OVX Rats After Administration of 17β-Estradiol at Three Doses.
Gonads |
E state |
||||||
---|---|---|---|---|---|---|---|
Control | Low E (10 μg/kg) | Metestrus | Medium E (50 μg/kg) | Proestrus | High E (150 μg/kg) | Pregnancy (GD 20–22) | |
Sham | 48.7±12.7 | 20.2±3.2 | 20.6±1.6 | 120.6±14.0 | 142.2±45.8 | 628.4±95.0 | 628±210 |
OVX | 5.5±0.6 | 17.9±3.5 | — | 125.8±15.7 | — | 660.4±59.4 | — |
Mean (±SEM) of serum level of estradiol 2 h after second injection (given 24 h apart) of 0, 10, 50, or 150 μg/kg of 17β-estradiol, in sham and OVX rats.
For comparison, levels found by Nequin et al (1979) along the cycle (metestrus and proestrus) and by Shaikh (1971) on gestation days (GD) 20–22 are provided.