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. 2010 Mar 24;35(7):1593–1604. doi: 10.1038/npp.2010.32

Figure 2.

Figure 2

Effect of daily treatment with rosiglitazone (Rosi, 5 mg/kg p.o.) for 4 weeks or 4 months on performance of J20 mice in the Morris water maze. (a) Escape latency in the invisible-platform training after 4 weeks of daily treatment. Both groups of transgenic mice showed significantly longer escape latencies in the invisible-platform training when compared with the non-transgenic (Non-Tg) littermate controls. (b) After 4 months of treatment, rosiglitazone ameliorated spatial memory in transgenic mice; escape latencies in the invisible-platform training were not different from those of non-transgenic mice. (c) Percentage time spent in the right quadrant during the 15 and 60 s probe trials after 4 months of treatment. Saline-treated J20 mice performed significantly worse than rosiglitazone-treated or Non-Tg littermate controls in the three 15- and 60-s probe trials. Values are means±SEM (n=11–12 animals per group). *P<0.05, **P<0.01, ***P<0.001 vs Non-Tg+sal, †P<0.01, ††P<0.01, †††P<0.001 vs J20+sal (ANOVA followed by Scheffé's t-test).