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. 2010 Mar 24;35(7):1593–1604. doi: 10.1038/npp.2010.32

Figure 6.

Figure 6

Chronic rosiglitazone treatment for 4 months reduced phosphorylated tau in transgenic mice (J20 line). (a) Representative images of p-tau aggregates in the hippocampus using the AT8 antibody. No p-tau staining was observed in non-transgenic (Non-Tg) mice. Numerous aggregates were observed in saline-treated transgenic mice and a marked reduction was found after Rosiglitazone treatment. (b) Representative images of p-tau aggregates in the hippocampus using the PHF1 antibody. The results obtained were similar to those depicted in a. (Scale bar=25 μm). (c) Number of p-tau aggregates using AT8 or PHF1 antibody. Quantitative data are means±SEM (n=4 animals per group). †P<0.05, †††P<0.001 vs J20+sal (Student's t-test).