Skip to main content
. 2010 Mar 3;35(7):1464–1476. doi: 10.1038/npp.2010.16

Figure 2.

Figure 2

Tesofensine induces hypophagia in the DIO rat. (a) Dose–response effect of tesofensine (0.1–3.0 mg/kg, s.c., n⩾6 per group) on total food intake in the DIO rat during a 12 h nocturnal period. Total food intake over the entire observation period is shown in gram (left y-axis) as well as relative to vehicle-treated DIO rats (right y-axis). (b) Time–response effect of incrementing doses of tesofensine (0.1–3.0 mg/kg, s.c.) on cumulated nocturnal food intake (2 h intervals). Data are shown as mean±SEM **p<0.01; ***p<0.001.