Figure 4.

Feeding kinetics of tesofensine-induced hypophagia in the DIO rat. (0.1–3.0 mg/kg, s.c., n⩾6 per group, overall dose–response effects on food intake in the same animals are shown in Figure 1). (a) total number of meals, (b) average meal size, (c) average meal duration, (d) latency to first meal, and (e) first meal size during a 12 h nocturnal period. Data are shown as mean±SEM ^*p<0.05, ^**p<0.01, ^***p<0.001 (compared with vehicle controls).