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Tesofensine-induced hypophagia does not involve α2 adrenoceptor, DA D2, DA D3, or 5-HT2A/C receptor function. Effect of (a) RX821002 (0.3 mg/kg, s.c.), (b) haloperidol (0.03 mg/kg, s.c.), (c) NGB2904 (0.1 mg/kg, s.c.), or (d) ritanserin (0.03 mg/kg, s.c.) on tesofensine-induced (1.5 mg/kg, s.c.) hypophagia in the DIO rat. Data are shown total nocturnal food intake (gram) as mean±SEM **p<0.01, ***p<0.001 (compared with vehicle controls).
