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. 2010 Mar 31;35(8):1751–1760. doi: 10.1038/npp.2010.42

Figure 1.

Figure 1

(a) Effects of prazosin pretreatment (0.25–1 mg/kg, i.p. 30 min before the session) on self-administration of nicotine (0.03 mg/kg/injection) under a FR5 schedule. N=14. (b) Effects of prazosin pretreatment (0.5–1 mg/kg, i.p. 30 min before the session) on self-administration of food pellets under a FR5 schedule. N=11. Data are expressed as means (±SEM) of the number of injections per session during baseline conditions (BL), during sessions with prazosin pretreatment, and during sessions with vehicle pretreatment and saline substitution (extinction, EXT). *p<0.05; **p<0.01, ***p<0.001 vs baseline (BL), Dunnett's test after significant ANOVA for repeated measures.