Figure 3.

Effect of prazosin pretreatment (0.25–1 mg/kg, i.p. 40 min before the session) on reinstatement of nicotine (a) or food (b) seeking after extinction induced by a priming injection of nicotine (0.15 mg/kg) or food priming, respectively. Data are expressed as means (±SEM) of the number of active lever presses during baseline conditions (BL) and during sessions with vehicle (0 mg/kg) or prazosin pretreatment. n=10 for nicotine priming and n=11 for food priming. ^*p<0.05; ^**p<0.01; ^***p<0.001 vs baseline; ^#p<0.05; ^##p<0.01 vs vehicle pretreatment (0); Student Newman–Keuls multiple comparison test after significant ANOVA for repeated measures.