Figure 3.

Improved performance of KAT II knock-out (KO) mice in passive avoidance (contextual memory) and spatial discrimination (T-maze) tests. (a) Performance of KAT II KO and wild-type (WT) mice in a passive avoidance paradigm. Latency is defined as the difference between the times taken to enter the dark compartment on the two test days. Data are the mean±SEM of 16 KAT II KO and 17 WT mice. ^*p<0.05 vs WT controls. (b) Number of correct choices (to locate a sucrose reward from a goal box) as a function of training days in a T-maze. Mice were 21 days old on the first day of the trial. Five correct choices represent chance (dashed line). (c) Latency to choose either the reinforced or the non-reinforced arm. Data in (b, c) are the mean±SEM of 19 KAT II KO and 15 WT mice. ^*p<0.05 vs WT controls.