Figure 4.

Enhanced LTP amplitude in hippocampal slices obtained from 21–28-day-old KAT II knock-out (KO) and age-matched wild-type (WT) mice. (a) All values are expressed relative to the baseline, ie the average of the responses during a 10 min period before LTP induction. Each point represents the average of the responses recorded in 60 s. Application of the NMDAR antagonist AP-5 (50 μM) blocked LTP in slices from either genotype. Data are the mean±SEM (12 slices per group). ^*p<0.05 vs WT controls. No significant genotypic differences were observed in NMDAR properties (resting membrane potential, firing pattern, and action potential amplitude) (b, c) or the AMPAR/NMDAR ratio (using average peak EPSCs at +40 mV) (d, e).