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. 2010 Mar 24;35(8):1718–1728. doi: 10.1038/npp.2010.36

Figure 1.

Figure 1

Acute darbepoetin alfa (D. alfa; 25 μg/kg, i.p.) treatment reversed object recognition deficits in STOP null mice. (a) Object exploration time in the sample phase. The time spent exploring objects is shown in the bar graph as mean±SEM. Wild-type mice (WT) and STOP null mice (KO) injected with vehicle (10 ml/kg, i.p.; WT: N=12, KO: N=13) or D. alfa (25 μg/kg, i.p.; WT: N=12, KO: N=16) spent equal amounts of time investigating the objects during the sample phase. (b) Discrimination ratio (d2) in the choice phase is shown in the bar graph as mean±SEM. KO mice treated with an acute injection of D. alfa (25 μg/kg i.p.) displayed a significant improvement in NORT performance compared with vehicle controls. White bars, vehicle (10 ml/kg, i.p.; WT: N=12, KO: N=13); black bars, D.alfa (25 μg/kg, i.p.; WT: N=12, KO: N=16). Two-way ANOVA with Bonferroni post hoc t-test, *p<0.05.