Table 3. Transmission Disequilibrium Test of ESR1 SNPs with Restrictive AN Subset of French Family-Based Cohort.

SNP#	Markers	TDT				Maternal TDT		Paternal TDT
		OT	T:U	p	OR (CI95)	p	OR (CI95)	p	OR (CI95)
1	rs488133	C	56:51	0.629	1.1 (0.8–1.6)	0.758	0.9 (0.5–1.7)	0.237	1.5 (0.8–2.9)
2	rs11155819	C	51:49	0.841	1 (0.7–1.5)	0.866	1.1 (0.5–2.1)	0.873	1.1 (0.6–2.0)
3	rs12199722	G	53:40	0.178	1.3 (0.9–2.0)	0.631	1.2 (0.6–2.2)	0.114	1.7 (0.9–3.2)
4	rs1884051	A	42:30	0.157	2.0 (1–3.8)	0.330	1.4 (0.7–2.6)	0.257	1.5 (0.7–3.3)
5	rs726281	A	48:24	0.005a	2.1 (1.2–3.6)	0.041	2.2 (1.0–4.9)	0.024	2.3 (1.1–4.8)
6	rs3020407	A	52:38	0.140	1.4 (0.9–2.1)	0.317	1.4 (0.7–2.7)	0.170	1.6 (0.8–3.2)
7	rs17081994	T	20:11	0.106	1.8 (0.9–3.8)	0.090	2.4 (0.8–6.8)	0.564	1.4 (0.4–4.4)
8	rs2982712	T	61:46	0.147	1.3 (0.9–1.9)	0.064	1.8 (1.0–3.4)	0.647	1.2 (0.6–2.1)
9	rs3020371	C	53:41	0.216	1.3 (0.9–1.9)	0.150	1.6 (0.8–3.0)	0.622	1.2 (0.6–2.2)
10	rs2228480	G	31:23	0.276	1.3 (0.8–2.3)	0.670	0.8 (0.4–1.9)	0.050	2.3 (1.0–5.2)
11	rs3798577	T	66:42	0.021	1.6 (1.1–2.3)	0.307	1.4 (0.8–2.4)	0.008	2.4 (1.2–4.7)
12	rs2295193	G	68:40	0.007	1.7 (1.2–2.5)	0.123	1.6 (0.9–3.0)	0.004	2.6 (1.3–5.3)
13	rs2252837	C	57:43	0.162	1.3 (0.9–2.0)	0.182	1.6 (0.8–3.1)	0.355	1.3 (0.7–2.5)

Abbreviations: OR (CI₉₅), odds ratio and the 95% confidence interval; OT, over-transmitted allele; T:U, transmitted vs untransmitted allele.

^aSignificant p-values are indicated in bold.