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. 2010 Nov 29;589(Pt 3):575–595. doi: 10.1113/jphysiol.2010.197608

Figure 4. Pharmacological dissection of class 2 and class 3 EPSPs.

Figure 4

For A–C, superimposed records of averaged class 2 EPSPs in control (black) and after perfusion with antagonist for ∼30 min (green) and the difference trace (blue). Control is fitted (offset thin black line) with the sum of two exponentials, τ3 and τ4. Monoexponential fits of the decays for the difference (τ3) and antagonist-insensitive (τ4) peaks are marked with offset thin black lines. A, 1.5 μm MLA, Control: τ3 = 4.9 and τ4 = 12.8 ms, Difference: τ3 = 4.5 ms, Antagonist insensitive: τ4 = 13.5 ms. B, 2 μm DHβE, Control: τ3 = 7.5 and τ4 = 11.3 ms, Difference: τ3 = 7.5 ms, Antagonist insensitive: τ4 = 13.2 ms. C, 200 nmα-Ctx GIC, Control: τ3 = 6.4 and τ4 = 16.7 ms, Difference: τ3 = 6.7 ms, Antagonist insensitive: τ4 = 20.2 ms. D, superimposed records of averaged of class 3 EPSP in control (black), after perfusion with 10 μmα-Ctx AuIB ∼30 min (green) and after washing out the antagonist for ∼15 min (grey). Control: τ4 = 14.4 ms, Mostly blocked: τ4 = 20.8 ms, after wash: τ4 = 24.9 ms.