Table 2. Genotype data for single nucleotide polymorphisms (SNPs) spanning the PTPN22 gene in patients with inflammatory polyarthritis (IP) and controls.
| SNP (no. from Carlton study) | Cases | Controls | p Value (uncorrected) | ||||||
| Sample size | 1/1 n (%) | 1/2 n (%) | 2/2 n (%) | Sample size | 1/1 n (%) | 1/2 n (%) | 2/2 n (%) | ||
| rs1217414 (SNP 1) | 736 | 386 (52.4) | 305 (41.4) | 45 (6.1) | 398 | 221 (55.6) | 161 (40.4) | 16 (4.0) | 0.16 |
| rs2488458 (SNP 2) | 746 | 425 (57.0) | 278 (37.3) | 43 (5.8) | 387 | 209 (54.0) | 156 (40.3) | 22 (5.7) | 0.45 |
| rs12760457 (SNP 18) | 731 | 355 (48.6) | 320 (43.8) | 56 (7.7) | 390 | 182 (46.7) | 179 (45.9) | 29 (7.4) | 0.67 |
| rs11102685 (SNP 20) | 742 | 614 (82.7) | 119 (16.0) | 9 (1.2) | 403 | 340 (84.4) | 61 (15.1) | 2 (0.5) | 0.35 |
| rs12730735(SNP 21) | 736 | 360 (48.9) | 322 (43.8) | 54 (7.3) | 357 | 169 (47.3) | 160 (44.8) | 28 (7.9) | 0.61 |
| rs2476601(SNP22) (PTPN22*C1858T) | 832 | 641 (77.0) | 178 (21.4) | 13 (1.6) | 412 | 342 (83.0) | 66 (16.0) | 4 (1.0) | 0.02 |
| rs1310182 (SNP 27) | 683 | 227 (33.2) | 323 (47.3) | 133 (19.5) | 351 | 101 (28.8) | 175 (49.9) | 75 (21.3) | 0.17 |
| rs1217388 (SNP 32) | 736 | 416 (56.5) | 275 (37.4) | 45 (6.1) | 400 | 208 (52.0) | 168 (42.0) | 24 (6.0) | 0.24 |
| ss38346942 (SNP 34) | 720 | 694 (96.4) | 26 (3.6) | 0 (0.0) | 386 | 375 (97.2) | 11 (2.8) | 0 (0.0) | 0.50 |
| rs1217413 (SNP 35) | 732 | 433 (59.2) | 259 (35.4) | 40 (5.5) | 383 | 240 (62.7) | 126 (32.9) | 17 (4.4) | 0.22 |
| rs3811021 (SNP 36) | 699 | 446 (63.8) | 215 (30.8) | 38 (5.4) | 386 | 247 (64.0) | 129 (33.4) | 10 (2.6) | 0.41 |
1, major (wild-type) allele; 2, minor (variant) allele.