Table 3. Allelic association of single nucleotide polymorphisms (SNPs) spanning PTPN22 gene with erosive status and Larsen score by 5 years.
| SNP (no. from Carlton study) | Erosive status by 5 years/minor allele frequency, n (%) | Median Larsen* score at 5 years, by allele† (IQR) | |||||
| Erosive, n (%) | Non-erosive, n (%) | OR (95% CI) | p Value | Allele 1 | Allele 2 | p Value‡ | |
| Rs1217414 (SNP 1) | 86 (26.9) | 114 (24.4) | 1.14 (0.8–1.6) | 0.43 | 5 (0–20) | 6 (0–29) | 0.72 |
| rs2488458 (SNP 2) | 73 (22.3) | 119 (24.9) | 0.86 (0.6–1.2) | 0.39 | 5 (0–21) | 4 (0–20) | 0.05 |
| rs12760457 (SNP 18) | 98 (30.4) | 150 (31.8) | 0.94 (0.7–1.3) | 0.69 | 4 (0–21) | 5 (0–19) | 0.52 |
| rs11102685 (SNP 20) | 34 (10.3) | 40 (8.4) | 1.30 (0.8–2.0) | 0.34 | 5 (0–20) | 9 (0–30) | 0.84 |
| rs12730735 (SNP 21) | 95 (29.5) | 147 (31.1) | 0.92 (0.7–1.3) | 0.62 | 4 (0–21) | 5 (0–19) | 0.63 |
| rs2476601 (SNP 22) (PTPN22*C1858T) | 45 (11.1) | 65 (11.6) | 0.96 (0.6–1.4) | 0.84 | 5 (0–20) | 5 (0–17) | 0.74 |
| ss38346944 (SNP 23) | 9 (3.0) | 8 (1.9) | 1.62 (0.6–4.1) | 0.32 | 5 (0–20) | 10 (2–30) | 0.32 |
| rs1310182 (SNP 27) | 133 (43.2) | 180 (44.6) | 0.95 (0.7–1.3) | 0.72 | 6 (0–23.5) | 5 (0–22) | 0.93 |
| ss38346943 (SNP 28) | 15 (4.7) | 19 (4.2) | 1.13 (0.6–2.2) | 0.72 | 5 (0–21) | 6 (2–20) | 0.26 |
| rs1217388 (SNP 32) | 72 (22.2) | 118 (24.8) | 0.87 (0.6–1.2) | 0.40 | 5 (0–21) | 4 (0–18) | 0.11 |
| ss38346942 (SNP 34) | 3 (1.0) | 10 (2.1) | 0.43 (0.1–1.5) | 0.19 | 5 (0–20) | 0 (0–7) | 0.06 |
| rs1217413 (SNP 35) | 64 (19.6) | 114 (24.5) | 0.75 (0.5–1.0) | 0.11 | 5 (0–22) | 3 (0–17) | 0.007 |
| rs3811021 (SNP 36) | 68 (22.2) | 99 (21.9) | 1.0 (0.7–1.4) | 0.92 | 5 (0–20) | 3 (0–20) | 0.49 |
Uncorrected p values are presented. Allele 1, major (wild-type) allele; allele 2, minor (variant) allele.
*Larsen score in all subjects with information available. When the analysis was restricted to patients who were erosive, the conclusions were not altered; †χ2; ‡logistic regression by genotype.
IQR, interquartile range; OR, odds ratio.