Table 2. Talairach Coordinates of Peak Areas of Activation Where Δ-9-THC and CBD had Opposite Effects During the Various Task Conditions.

Area	Talairach coordinates			Cluster size	p
	x	y	z
Opposite effects of Δ-9-THC and CBD during the retrieval condition of the verbal memory task
Striatum	11	22	4	14	<0.001
	7	4	−7
	−7	15	4	16	<0.001
	−7	4	−7
Anterior cingulate/medial prefrontal cortex	−7	48	9	54	<0.001
Lateral prefrontal cortex	−40	30	26	16	0.003
Opposite effects of Δ-9-THC and CBD during the fearful faces task
Amygdala	−18	−4	−18	9	0.03
Cerebellum	29	−59	−18	33	0.006
	−18	−81	−24	24	0.009
Fusiform gyrus	−25	−81	−13	8	0.002
Lingual gyrus	−25	−85	−7	6	0.03
Lateral prefrontal cortex	−29	30	31	8	0.03
Opposite effects of Δ-9-THC and CBD during the response inhibition task
Parahippocampal gyrus	−32	−41	−7	14	0.003
	29	−44	−7	62	0.003
Insula	−25	−22	26	54	0.004
Caudate	−29	−33	4	9	0.01
Opposite effects of Δ-9-THC and CBD during auditory processing
Right temporal cortex	54	−15	−2	73	0.005
	54	−33	4	70
Left temporal cortex	−51	−26	−2	21	<0.001
Insula	51	−37	20	13	0.025
	−40	−15	9	12	0.025
Opposite effects of Δ-9-THC and CBD during visual processing
Right occipital cortex	14	−81	20	136	<0.001
	43	−67	4	19
Left occipital cortex	−14	−78	9	9	0.01