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The glutamine/glutamate (Gln/Glu) ratio in the anterior cingulate cortex (ACC) and parieto-occipital cortex (POC) as measured by J-resolved proton magnetic resonance spectroscopy (1H-MRS) at baseline, day 2 of riluzole treatment, and week 6 of riluzole treatment. Dashed line shows the mean Gln/Glu ratio in combined ACC and POC as measured by 1H-MRS at baseline, day 2 of riluzole treatment, and week 6 of riluzole treatment. Error bars represent 95% confidence interval.
