Table 2. Association of Markers in GRIK4 with Treatment Response and Remission.

GRIK4 dbSNP ID	Unipolar (n=270)				Uni-/Bipolar (n=300a)
	Responseb		Remissionc		Response		Remission		SNP information
	pemp				pemp
	Genotypic	Allelic	Genotypic	Allelic	Genotypic	Allelic	Genotypic	Allelic	Alleles	Protective genotype	Function	MAF
rs12800734	0.015	0.047	0.0043	0.087	0.0035	0.077	0.0019	NS	A/G	GG	Intron 16	0.45
rs2276319	0.025	0.045	0.014	0.084	0.0073	0.076	0.0067	NS	C/T	CC	Intron 16	0.45
rs1621211	0.0076	NS	0.017	NS	0.0091	NS	0.011	NS	A/G	AA	5′ end	0.26
rs513548	0.062	NS	0.016	NS	0.066	NS	0.011	NS	T/G	GG	Intron 17	0.27
rs2282586	NS	NS	0.014	0.097	NS	NS	0.018	NS	A/G	GG	5′ end	0.37
rs2156633	0.0021	0.048	NS	NS	0.0010	0.081	NS	NS	A/G	GG	Intron 11	0.22
rs1944522	0.013	0.088	NS	NS	0.0044	NS	NS	NS	A/G	AA	5′ end	0.46
rs1954787d	NS	NS	NS	NS	NS	NS	0.079	NS	C/T	CC	Intron 1	0.42
FPM (82 SNPs)	0.088	NS	0.026	NS	0.028	NS	0.029	NS

Abbreviations: p_emp, empirical p-value; NS, not significant; MAF, minor allele frequency; FPM, Fisher's product method (Fisher, 1932), gene-wise association results.

^a270 unipolar and 30 depressed bipolar patients.

^bA 50% reduction in the baseline HAM-D score after 5 weeks.

^cHAM-D score of <10 (21 items version) after 5 weeks.

^dBest GRIK4 SNP of the STAR^*D study (Paddock et al, 2007).