Table 3. Association of Markers in HTR2A with Treatment Response and Remission.

HTR2A dbSNP ID	Unipolar (n=270)				Uni-/Bipolar (n=305a)
	Responseb		Remissionc		Response		Remission		SNP information
	pemp				pemp
	Genotypic	Allelic	Genotypic	Allelic	Genotypic	Allelic	Genotypic	Allelic	Alleles	Prot. allele/ genotype	Function	MAF
rs17288723	NS	NS	0.0040	0.046	NS	NS	0.0011/0.02d	0.017	C/T	CC	Intron 2	0.14
rs2770297	NS	NS	0.028	0.099	NS	NS	0.0055	0.087	C/T	CC	Intron 2	0.27
rs2070037	NS	NS	NS	0.074	NS	0.074	0.027	0.011	C/T	C	Intron 1	0.23
rs2770302	NS	NS	NS	0.099	NS	NS	0.033	0.015	T/A	T	Intron 1	0.24
rs2296973	NS	NS	0.050	0.056	NS	NS	0.033	0.018	T/G	T	Intron 1	0.29
rs7997012e	NS	NS	NS	NS	NS	NS	NS	0.043	A/G	G	Intron 2	0.45
FPM (37 SNPs)	NS	NS	NS	NS	NS	NS	0.012	0.024

Abbreviations: p_emp, empirical p-value; NS, not significant; prot., protective; MAF, minor allele frequency; FPM, Fisher's product method (Fisher, 1932), gene-wise association results.

^a275 unipolar and 30 depressed bipolar patients.

^bA 50% reduction in the baseline HAM-D score after 5 weeks.

^cHAM-D score of <10 (21 items version) after 5 weeks.

^dAfter Westfall–Young correction for the number of SNPs tested.

^eBest HTR2A SNP of the STAR^*D study (McMahon et al, 2006).