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. 2010 May 19;35(9):1921–1931. doi: 10.1038/npp.2010.64

Table 4. Associations Between CHRN SNPs and Dependence Phenotypes in the Case–Control Sample.

SNP GENE POS (BP) Min (AA/EA) MAF AA MAF EA Alcohol dependence
 Cocaine dependence
 Opioid dependence
 Nicotine dependence
            AA (N=1537)
 EA (N=1016)
 AA (N=1708)
 EA (N=1186)
 AA (N=1721)
 EA (N=1210)
 AA (N=1745)
 EA (N=1232)
            OR P Pemp OR P Pemp OR P Pemp OR P Pemp OR P Pemp OR P Pemp OR P Pemp OR P Pemp
rs3841324 CHRNA5 76644868 A 0.21 0.37 0.78 0.03 0.28 0.87 0.34 0.94 0.87 0.25 0.99 0.96 0.88 1 0.93 0.43 1 1.03 0.41 1 0.95 0.70 1 1.02 0.55 1
rs684513 CHRNA5 76645455 G 0.20 0.24 1.24 0.04 0.63 1.15 0.32 0.99 1.43 0.002 0.01 1.03 0.47 1 0.79 0.04 0.83 1.08 0.16 1 1.07 0.65 1 1.00 0.72 1
rs621849 CHRNA5 76659916 G 0.43 0.39 0.80 0.007 0.14 0.92 0.46 0.99 0.82 0.02 0.30 1.00 0.86 1 1.10 0.25 1 1.07 0.39 0.99 0.88 0.08 0.83 1.03 0.59 1
rs16969968 CHRNA5 76669980 A 0.06 0.34 0.99 0.763 1 0.98 0.74 1 1.14 0.54 1 0.98 0.61 1 1.45 0.23 0.64 0.90 0.08 0.98 1.43 0.02 0.30 1.06 0.93 1
rs615470 CHRNA5 76673043 T 0.39 0.35 0.77 0.0004 0.02 0.85 0.22 0.93 0.84 0.04 0.51 0.90 0.37 0.99 1.00 0.69 1 0.99 0.98 1 0.89 0.11 0.96 0.95 0.96 1
rs578776 CHRNA3 76675455 G/A 0.45 0.31 0.78 0.002 0.03 1.17 0.13 0.96 0.89 0.20 0.99 1.09 0.28 0.99 1.13 0.24 0.99 1.17 0.02 0.81 0.98 0.80 1 0.98 0.78 1
rs6495307 CHRNA3 76677376 T 0.41 0.39 0.82 0.01 0.30 0.82 0.11 0.65 0.87 0.19 0.93 0.87 0.23 0.94 1.01 0.69 1 0.97 0.94 1 0.94 0.53 1 0.93 0.80 1
rs1051730 CHRNA3 76681394 A 0.11 0.35 1.05 0.49 1 1.02 0.82 1 0.98 0.66 1 0.97 0.41 1 1.17 0.64 1 0.86 0.02 0.65 1.15 0.20 1 1.07 0.78 1
rs3743078 CHRNA3 76681814 G/C 0.41 0.27 0.79 0.006 0.07 1.13 0.11 0.99 0.86 0.07 0.88 1.02 0.64 1 1.25 0.04 0.30 1.12 0.11 0.99 0.96 0.70 1 0.92 0.65 1
rs12914385 CHRNA3 76685778 T 0.18 0.38 0.98 0.9631 1 1.02 0.83 1 0.99 0.84 1 0.98 0.58 1 1.00 0.56 1 0.91 0.13 0.99 1.22 0.05 0.51 1.13 0.37 0.93
rs2869546 CHRNA3 76694400 C 0.38 0.36 0.82 0.009 0.30 0.80 0.09 0.58 0.96 0.60 1 0.91 0.45 0.99 0.89 0.31 1 0.98 0.89 1 0.94 0.35 1 0.95 0.78 1
rs8040868 CHRNA3 76698236 C 0.34 0.41 1.07 0.33 1 1.09 0.76 0.99 0.94 0.56 1 1.01 0.67 1 1.06 0.97 1 0.91 0.09 0.99 1.00 0.94 1 1.09 0.54 0.99
rs11637890 CHRNB4 76722474 G 0.15 0.35 0.85 0.24 0.99 0.92 0.25 1 0.91 0.93 1 0.96 0.61 1 1.20 0.10 0.99 1.06 0.41 1 0.91 0.91 1 1.03 0.66 1

Abbreviations: AA, African American; EA, European American; MAF, minor allele frequency; Min, minor allele; P, Raw P-value; Pemp, Empirical P-value based on 1000 null simulations; OR, odds ratio for each additional copy of the minor allele.

Values with an experiment-wide significance less than 0.05 are in bold.

N indicates the total number of subjects contributing to each analysis.