Table 5. Nicotinic Receptor Haplotypes Associated with Substance Dependence Traits.
SNPs | Alleles (Freq case/control) | Sample | Phenotype | P-value (global/haplotype) |
---|---|---|---|---|
rs3841324, rs684513 | A–C (0.22/0.26) | EA families | OD | 0.03/0.01 |
rs615470, rs578776 | C–A (0.51/0.57) | AA case–control | AD | 0.005/0.001 |
rs621849, rs16969968 | A–A (0.05/0.08) | AA case–control | OD | 0.008/0.01 |
Alleles shown represent the haplotype with the strongest effect on the trait of interest and the haplotype frequency in cases and controls.