Figure 7.

Scanning electron microscopy of (A and B) diffusion chambers innoculated with HUCPVCs and implanted intraperitoneally in rats for 4 and 7 days respectively. A fibrillar extracellular matrix is evident at both time points. The exposed cellulose acetate filter (f) seen at 4 days but not at 7 days suggests continued HUCPVC synthetic activity in vivo to 7 days. (C and D) Freeze fractured 4 mm diameter full thickness circular defects at 7 days post-operative (C) from fibrin-only control wound; (D) from fibrin + HUCPVC wound. Note, in the latter, the organized stratified appearance of the ECM.