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. 2010 Oct 6;36(2):423–433. doi: 10.1038/npp.2010.173

Figure 7.

Figure 7

Nordexfenfluramine and food consumption in 5-HT2B−/−, SERT−/−, and SB242084-treated WT mice. (a) Treatment with 5 mg/kg NDF led to a significant decrease in food intake after 1 h in WT and 5-HT2B−/− mice, although to a lower extent (NDF simple effect, F(1, 34)=31.64, p<0.0001; n=9 to 10). (b) Similarly, treatment with 5 mg/kg NDF also led to a significant decrease in food intake after 1 h in WT and SERT−/− mice to a lower extent (NDF simple effect, F(1, 24)=38.81, p<0.0001; n=5–10). (c) In contrast, pretreatment of WT mice with the 5-HT2C receptor antagonist, SB242084 (0.5 mg/kg), failed to alter the NDF-induced hypophagia (NDF simple effect, F(1, 39)=76.48, p<0.0001; n=7–15). Bonferroni tests were used for post hoc comparisons. *p<0.05, ***p<0.001 compared with the vehicle group; §p<0.05 compared with the WT group. All results are expressed as mean±SEM.