Figure 3.
A1 receptors modulate the CB1-mediated inhibition of [3H]glutamate. (a) Blockade of A1 receptors by DPCPX (50 nM) did not modify (p>0.05, n=4) the effect of WIN55,212-2 (WIN, 1 μM). (b) The inhibition induced by WIN (1 μM) was significantly (**p<0.01, n=5) attenuated by CPA (100 nM), but the effect of CPA alone (applied before S2) was not modified (p>0.05, n=4) when applied in the presence of WIN (1 μM). Bars represent the mean±standard error of mean of 4–5 individual experiments performed in duplicate. The S2/S1 values from controls were taken as 0% within each experiment. P-values were obtained by paired Student's t-test, compared with corresponding controls within the same batch of synaptosomes.