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. 2010 Nov 24;36(3):692–700. doi: 10.1038/npp.2010.202

Figure 5.

Figure 5

Rat brain CYP2B manipulation shifts the propofol sleep-time dose–response curve. A dose of 40 mg/kg was inactive at baseline—none of the animals slept (sleep time: 0 min). An intracerebroventricular (i.c.v.) injection of C8-xanthate (C8-X) significantly increased sleep time consequently rendering the 40 mg/kg dose active (sleep time: 9 min; apparent dose: 62 mg/kg; P=0.009; n=9). Upon administration of a 50 mg/kg dose of propofol, the animals slept an average of ∼5 min at baseline. Induction of brain CYP2B activity by 7-day nicotine treatment abolished the propofol response—none of the animals slept (sleep time: 0 min; apparent dose: 40 mg/kg; P=0.02; n=9). After i.c.v. C8-X, the rats displayed significantly longer sleep times (sleep time: 19 min; apparent dose: 70 mg/kg; P=0.04; n=9). Dashed arrows indicate apparent dose (graph is plotted on a log x axis, but values on x axis are actual doses).