Fig. 7. Co-expression of sKvLQT1 with C–terminal KvLQT1 deletion constructs suppressed functional expression of KvLQT1 currents. (A) Data pooled from a number of experiments in which cRNAs encoding the deletion constructs sKvLQT1Δ511–564, sKvLQT1Δ511–534 and sKvLQT1Δ354–510 were co-expressed with sKvLQT1 (wt) cRNA in Xenopus oocytes. Peak amplitudes were measured following a 4 s test pulse to +40 mV from a holding potential of –80 mV. The bars represent the mean of measurements from 4–20 different oocytes. The 100% Irel value is as in Figure 1D. (B) Experiments were carried out as in (A) except that wt sKvLQT1 cRNA was co-injected with sKvLQT1Δ590–676, sKvLQT1Δ511–620, sKvLQT1Δ115–589 and sKvLQT1 JLN. Bars are as for (A). Means were derived from between 7 and 36 cells.