Table 4.
Genes whose expression is different due to genotype
| Gene | KO/C | Protein Name/Function |
|---|---|---|
| Regulation | ||
| Rarb | 1.66 | retinoic acid receptor beta |
| Metabolism | ||
| Acp2 | 1.51 | acid phosphatase 2 |
| Anxa2 | 1.60 | annexin A2; calpactin 1 |
| Anxa5 | 1.60 | annexin A5 |
| Ces6 | 2.11 | carboxylesterase 6 |
| Idh2 | 1.56 | isocitrate dehydrogenase |
| Lpl | 2.53 | lipoprotein lipase |
| Rarres1 | 1.63 | retinoic acid receptor responder 1 |
| Sdro | 0.53 | orphan short chain dehydrogenase |
| Smpd3 | 1.85 | sphingomyelin phosphodiesterase 3 |
| Membrane Transport | ||
| Abcb1a | 2.38 | ATP-binding cassette |
| Abcc3 | 2.28 | ATP-binding cassette |
| Slc16a7 | 1.62 | solute carrier family 16 transporter |
| Slc3a1 | 0.63 | solute carrier family 3 a1 transporter |
| Slco1a4 | 3.10 | solute carrier family 1a4 transporter |
| Oxidative Stress | ||
| Gpx7 | 1.76 | glutathione peroxidase 7 |
| Gsta1 | 2.91 | glutathione S-transferase a1 |
| Gsta4 | 1.56 | glutathione S-transferase m4 |
| Gstm1 | 1.53 | glutathione S-transferase m1 |
| Gstm3 | 8.46 | glutathione S-transferase m3 |
| Inflammatory Response | ||
| Akr1b3 | 1.51 | aldo-keto reductase family1b3 |
| Akr1b7 | 1.97 | aldo-keto redcutase family 1b7 |
| Il1rn | 2.01 | interleukin 1 receptor antagonist |
| Hspb1 | 1.51 | heat shock protein 1 |
| Lcn2 | 3.93 | lipocalin 2 |
| Mmp12 | 3.00 | matrix metallopeptidase 12 |
| Orm3 | 2.16 | orosomucoid 3 |
| Serpinb1a | 2.96 | serpin peptidase inhibitor b1a |
| Serpinb6b | 2.08 | serpin peptidase inhibitor 6b |
| Serpina4 | 0.36 | serpin peptidase inhibitor a4 |
| Tgfbr2 | 1.56 | transforming growth factor |
| Tnfrs19 | 2.23 | tumor necrosis factor receptor 19 |
| Cytochrome P450 Enzymes | ||
| Cyp1a2 | 1.56 | cytochrome P450 1a2 |
| Cyp26a1 | 2.69 | cytochrome P450 26a1 |
| Cyp2b1 | 127.69 | cytochrome P450 2b10 |
| Cyp2c54 | 1.67 | cytochrome P450 2c54 |
| Cyp2c55 | 17.87 | cytochrome P450 2c55 |
| Cyp2u1 | 0.65 | cytochrome P450 2u1 |
| Cyp3a41a | 1.86 | cytochrome P450 3a41a |
| Ubiquitination | ||
| Usp18 | 1.57 | ubiquitin-specific peptidase 18 |
| Ubd | 2.38 | ubiquitin D |
| Yod1 | 0.65 | YOD1 deubiquitinating enzyme 1 |
| Others | ||
| Basp1 | 1.52 | brain abundant |
| Casc4 | 1.51 | cancer susceptibility candidate 4 |
| Cml4/Nat8 | 0.56 | camello-like 4; N-acetyl tranferase |
| Cotl1 | 1.64 | coactosin-like 1 (Dictyostelium) |
| D1Ertd471e | 1.82 | DNA segment |
| Eid1 | 1.50 | EP300 interacting inhibitor of differentiation 1 |
| Entpd5 | 1.65 | ectonucleoside triphosphate diphosphohydrolase 5 |
| Flvcr2 | 1.55 | feline leukemia virus subgroup C cellular receptor family |
| Gdf15 | 1.91 | growth differentiation factor 15 |
| H2-Aa | 1.54 | histocompatibility 2 |
| Lgals7 | 1.67 | lectin |
| Ndrg1 | 1.82 | N-myc downstream regulatory gene 1 |
| Nebl | 4.79 | nebulette; thin filament protein |
| Ptpla | 1.50 | protein tyrosine phosphatase-like |
| Pvr | 1.59 | poliovirus receptor |
| Pvt1 | 1.70 | plasmacytoma variant translocation 1 |
| Rhbg | 1.66 | Rhesus blood group-associated B glycoprotein |
| Rragd | 1.91 | Ras-related GTP binding D |
| Snx17 | 0.60 | sorting nexin 17 |
| Sulf2 | 1.54 | sulfatase 2 |
| Tlr2 | 1.52 | Toll-like receptor 2 |
| Tmed3 | 1.51 | transmembrane emp24 domain containing 3 |
| Tmem120a | 0.47 | transmembrane protein 120A |
| Tmem176a | 1.53 | transmembrane protein 176A |
| Tmem51 | 1.53 | transmembrane protein 51 |
| Ugt2b37 | 2.73 | UDP glucuronosyltransferase 2 family |
| Unknowns | ||
| 1810023F06Rik | 1.61 | RIKEN cDNA 1810023F06 |
| 4931406C07Rik | 1.71 | RIKEN cDNA 4931406C07 |
| ? | 2.29 | 0 day neonate lung cDNA |
Data are expressed as ratio of LCN vs. control (KO/C) when identified as significant at q < 0.05 using the t-test with Benjamini-Hochberg FDR correction. Protein/function identification is from the UniProtKB/Swiss-Prot Database.