Table 5.

Hepatic genes whose expression is significantly different due to both diet and genotype

Gene	Ctl L	KO L	Ctl C	KO C	Ctl FF	KO FF	P Value	Protein Name/Function
								Fatty Acid Metabolism
Elovl1	0.02	0.30	−0.20	0.08	−0.64	−0.01	0.011	FA elongation
Lcn13	−0.15	−0.81	−0.14	−0.58	2.81	0.13	0.003	lipocalin 13
Lpl	−0.20	0.89	−0.59	0.43	−0.35	1.55	0.003	lipoprotein lipase
Ppt1	−0.02	0.01	−0.07	−0.07	0.18	0.04	0.014	palmitoyl-protein thioesterase 1
								Inflammation/Inflammatory Response
Mmp12	−0.44	2.43	−0.15	0.83	−0.23	0.68	0.012	matrix metallopeptidase 12
								Regulation
Vegfb	0.20	0.18	0.17	−0.07	−0.62	−0.30	0.007	vascular endothelial growth factor B
Creb3l2	−0.25	0.21	−0.16	0.02	0.01	0.01	0.002	cAMP responsive element binding protein 3-like 2
								Others
Adamts16	0.17	−0.02	0.01	0.00	0.00	−0.09	0.011	A disintegrin-like and metallopeptidase
Clcn6	0.01	0.20	−0.03	−0.01	−0.33	0.04	0.006	chloride channel 6
Col23a1	0.00	−0.27	0.07	0.03	0.00	−0.02	0.001	procollagen
Dsn1	−0.11	0.27	−0.14	0.06	0.03	0.00	0.002	MIND1 kinetochore complex component
Gpc1	0.44	−0.07	0.56	−0.14	−0.25	−0.10	0.000	glypican 1
Gpr137b	−0.38	0.94	−0.25	0.12	0.04	0.20	0.008	G protein-coupled receptor 137B
Neu1	−0.08	0.05	0.00	0.07	−0.24	0.13	0.009	neuraminidase 1
Odf1	0.01	0.04	0.12	−0.21	0.02	−0.15	0.002	outer dense fiber of sperm tails 1
Rbpms	−0.35	0.03	−0.32	0.02	0.08	0.13	0.014	RNA binding protein gene with multiple splicing
Sgcg	0.14	−0.19	0.18	−0.16	0.01	−0.04	0.002	sarcoglycan
Tmem120a	0.23	−0.39	0.49	−0.33	0.52	−1.27	0.003	transmembrane protein 120A
Tmem97	0.05	0.24	0.01	0.13	−0.65	−0.02	0.015	transmembrane protein 97
Wdr51b	0.24	0.11	−0.16	−0.06	−0.07	0.02	0.004	WD repeat domain 51B
Wrnip1	−0.24	0.11	−0.11	0.05	−0.10	0.35	0.014	Werner helicase interacting protein 1
								Unknown
	−0.01	−0.01	0.06	−0.12	0.21	−0.03	0.003	RIKEN cDNA 9030224M

Log2 transformed fold change and significance were calculated by 2-way ANOVA, q < 0.01. Ctl, control; KO, LCN; L, lard; C, canola; FF, fish/fungal.