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Response to loreclezole is absent in 5-HT neurons of WKY rats. (a) A representative averaged mIPSC and trace (inset) from a 5-HT neuron in a SD (left) or WKY (right) rat before and after 10 μM loreclezole application, an anti-convulsant that selectively binds to the β2/3 subunits. (b) Loreclezole had no effect on mIPSC amplitude in either SD or WKY rats (p>0.05), (c) and only significantly prolonged mIPSC fast decay in SD animals (p<0.05), but not WKY animals (p>0.05).
