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. 2010 Dec 8;36(4):805–818. doi: 10.1038/npp.2010.214

Figure 1.

Figure 1

CB1 upregulation is elicited by stress exposure in mouse prefrontal cortex in a glutamate-related mechanism. (a) Western blot and densitometric analysis of CB1 band in the prefrontal cortex of control (CWT) and stressed during 4 days (SWT) wild-type mice, and control (CKO) and stressed (SKO) CB1 KO mice. The densitometric data are normalized by β-actin (lower band) and are representative of three experiments. *p<0.05 vs CWT (one-way ANOVA followed by Newman–Keuls post hoc test). AU: arbitrary units. (b) Q-PCR analysis of CB1 mRNA in the prefrontal cortex of control (CWT), stressed during 4 days (SWT), stressed + ACEA (SWT + ACEA), and stressed + MK-801 (SWT + MK) wild-type mice. Data are normalized by tubulin, and are representative of three experiments. *p<0.05 vs CWT; #p<0.05 vs SWT (one-way ANOVA followed by Newman–Keuls post hoc test. AU, arbitrary units. (c) Western blot and densitometric analysis of CB1 band in the prefrontal cortex of control (CWT), stressed during 4 days (SWT), stressed + ACEA (SWT + ACEA), and stressed + MK-801 (SWT + MK) wild-type mice. Data are normalized by β-actin and are representative of three experiments. *p<0.05 vs CWT; #p<0.05 vs SWT (one-way ANOVA followed by Newman–Keuls post hoc test). AU, arbitrary units.