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FA staining of Nrl−/− and Nrl−/−Grk1−/− mice. Images represent the right quadrant of the right eye of each animal at 1, 3, 5, and 7 months of age. Top: Nrl−/−Grk1−/− retinas. (bottom) Nrl−/− controls. Arrows: Leakage of blood vessels in Nrl−/−Grk1−/− mice that begins at 1 month and progresses with age. Retinas from age-matched Nrl−/− mice appear normal with healthy vasculature patterns. Images were taken at approximately 7 minutes after injection of the fluorescein dye.
