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Effect of inhibition of Rap-1 on dbcAMP-stimulated decrease in basal MAPK activity. Lacrimal gland acini were incubated with the Rap-1 inhibitor GGTI-298 (10−7–10−5 M) for 10 minutes before the addition of dbcAMP (10−3 M) for 30 minutes. Western blot analysis was performed using antibodies against phosphorylated p42/p44 MAPK (A). Data are mean ± SEM of four independent experiments. *Significant difference from basal. Representative blot of MAPK (B).
