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. 2010 Dec;51(12):6566–6574. doi: 10.1167/iovs.10-6161

Figure 1.

Figure 1.

Effect of anti-CD25 on ACAID and corneal allograft survival. BALB/c mice were treated with anti-CD25 antibody or isotype control once before and once weekly after AC injection or corneal transplantation. (A) ACAID was induced on day 0 with C57BL/6 splenic nonadherent cells. A SC injection of C57BL/6 splenocytes was given on day +7. DTH challenge with mitomycin C–treated C57BL/6 cells was on day +14. Negative control animals received an ear challenge only (n = 5 for all groups). This experiment was performed twice with similar results. (B) C57BL/6 corneal allograft survival in BALB/c mice treated with anti-CD25 or rat IgG isotype control antibody. C57BL/6 corneal allografts underwent rejection in 50% of hosts treated with the isotype control IgG (n = 10) and had an MST of 52 days. C57BL/6 corneal allografts transplanted to BALB/c recipients treated with anti-CD25 were rejected in 100% of hosts with an MST of 26 days (n = 10). P < 0.05 between anti-CD25–treated group and rat IgG isotype control treated allograft recipients. The experiment was performed twice with similar results.