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. 2010 Dec;51(12):6566–6574. doi: 10.1167/iovs.10-6161

Figure 6.

Figure 6.

Effect of anti-IFN-γ on ACAID and corneal allograft survival. (A) Mice were treated with 500 μg anti-IFN-γ or isotype control antibody on days −1 and +7. ACAID was induced with nonadherent C57BL/6 spleen cells on day 0, followed by SC immunization with C57BL/6 splenocytes on day +7. DTH challenge was performed with mitomycin C-treated C57BL/6 cells on day 14. P = 0.002 between anti-IFN-γ and isotype control (n = 5). This experiment was performed 2 additional times with similar results. (B) BALB/c animals were treated with anti-IFN-γ antibody or isotype control on days −4 and −2 and twice weekly after corneal transplantation. Ninety percent of BALB/c hosts treated with anti-IFN-γ rejected their C57BL/6 corneal allografts with a MST of 19 days (n = 10). The incidence of C57BL/6 corneal allograft rejection in BALB/c mice treated with an isotype control was 50% (n = 10) and with a MST of 46 days (P < 0.05).