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The TSP-1 KO mouse has prostate hyperplasia. Compared to wildtype (WT), the TSP-1 KO (TSP KO) mouse prostate demonstrated epithelial and stromal cell hyperplasia by 3 months of age with nuclear atypia (hyperchromatic and pleomorphic nuclei) in the glandular cells. Evidence of hyperplasia was observed in the ventral prostate (VP), dorsal prostate (DP) and lateral prostate (LP). Representative H&E sections are shown at 5-6 months of age.
